CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...
The evidence "for Asf1 accepting histones at the replication fork was really interesting to me, as no factor involved in chromatin disassembly at the DNA replication fork has been proposed to date to ...
EurekAlert!: CDT1 overexpression suppresses DNA replication and induces DNA damage, suggesting a mechanism for cancer development
CDT1 overexpression suppresses DNA replication and induces DNA damage, suggesting a mechanism for cancer development
EurekAlert!: A protein thought to play a supporting role in DNA replication actually facilitates the whole process
Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...
A protein thought to play a supporting role in DNA replication actually facilitates the whole process
A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...
CBS News: DNA from fork leads to arrest of Florida man 15 years after uncle killed in NYC
A man in Florida has been indicted on a second-degree murder charge in the 2009 killing of his uncle in New York City after authorities say DNA collected from a discarded fork linked him to the crime.
DNA from fork leads to arrest of Florida man 15 years after uncle killed in NYC