Abstract Recent studies have demonstrated the complex coordination of pro-inflammatory signaling and reactive microglia/macrophage on the formation Müller glial-derived progenitor cells (MGPCs) in the retinas of fish, birds and mice.
The LNPs coated with immortalized Müller CMs achieved significantly higher transfection efficiencies and better targeting for Müller cells compared to that of those coated with primary CMs; moreover, the former LNPs exhibited sustained drug release and targeting effects for up to three days, both in vitro and in vivo.
Although platelet derived growth factor (PDGF) receptor expression in Müller glia has been reported earlier, their actual role for Müller cell function and intimate interaction with cells of the retinal neurovascular unit remains unclear.
Müller glia play diverse, critical roles in retinal homeostasis, which are presumably enabled by their complex anatomy. However, much remains unknown, particularly in mouse, about the anatomical arrangement of Müller cells and their arbors, and how these features arise in development.
Abstract Müller cells (MCs) are the most common glial cell found in the human retina. MCs have an important role in architectural and metabolic functions in the retina.
This study reviews this feature's molecular and clinical approaches, focusing on the critical signaling pathways, generation and transplantation methods, and clinical and sub-clinical challenges. Keywords: Müller glial cells; Regenerative medicine; Retina; Retinal degenerative diseases.
Potential of Müller Glial Cells in Regeneration of Retina ... - PubMed
This review considers the potential roles of Müller cells in fibrocontractive retinal disorders and, in particular, evidence that Müller cells function as an effector cell type in traction retinal detachment associated with PVR and PDR.