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OGM technology labels ultra-high molecular weight DNA at a specific sequence motif (CTTAAG) occurring approximately 14-16 times per 100kb in the human genome. The long fluorescently labeled DNA molecules are linearized and imaged in nanochannel arrays in a high throughput, automated manner.
Discover optical genome mapping (OGM), a workflow that combines various technologies for one purpose: to reveal structural variation in a way that’s never been done before.
OGM relies on a specifically designed extraction protocol facilitating the isolation of ultra-high molecular weight (UHMW) DNA. This protocol utilizes a paramagnetic disk purposed with trapping DNA for wash steps thereby reducing sheering forces present in standard column-based extraction methods.
Background/Objectives: Optical genome mapping (OGM) has recently emerged as a new technology in the clinical cytogenomics laboratories. This methodology has the ability to detect balanced and unbalanced structural rearrangements using ultra-high molecular weight DNA.
Optical genome mapping (OGM) is a novel method enabling the detection of structural genomic variants.
Value of Optical Genome Mapping (OGM) for Diagnostics of Rare Diseases ...
By briefly discussing OGM, along with its major advantages and limitations, we underscore the importance of karyotype-based genomic research, from both a theoretical framework and a new technology perspective.
Optical genome mapping (OGM) has emerged as a next-generation cytogenomic technology that can detect all classes of SVs at a higher resolution than the SOC techniques.
Unlike traditional sequencing methods that focus on microscopic details, OGM converts DNA into a “barcode” whose profile can resolve copy number and structural variations without needing sequence-level data.