The blood–brain barrier (BBB) is often an obstacle for the effective delivery of therapeutics to the brain. Intranasal delivery through the olfactory epithelium (OE) can bypass the BBB but some ...
Seemingly unrelated diseases and conditions like Alzheimer's disease, obesity, chronic pain, traumatic brain injury, and multiple sclerosis disrupt the blood-brain barrier. Peter Searson's lab is ...
Phys.org on MSN: Crossing the blood–brain barrier with a payload via engineered bacteria
Researchers at the National University of Singapore have reported crossing the blood–brain barrier with help from a modified Lactobacillus plantarum. By delivering an appetite-regulating hormone ...
MSN: Alzheimer's signals in nasal swabs; gabapentin and autism; leaky blood-brain barrier
MedCity News: GSK Grabs Rights to Technology That Gets Drugs Across the Blood-Brain Barrier
The properties of the blood-brain barrier serve a vital protective role, but they also keep drugs from reaching the organ. Big pharmaceutical companies have been making deals for technologies that ...
GSK Grabs Rights to Technology That Gets Drugs Across the Blood-Brain Barrier
Getting drugs to the brain is difficult. The very thing designed to protect the brain's environment — the blood-brain barrier (BBB), tightly packed cells that prevent most substances from passing ...
MedPage Today: Alzheimer's Signals in Nasal Swabs; Gabapentin and Autism; Leaky Blood-Brain Barrier
Business Wire: Preclinical Analyses of TGR-63 Demonstrate Blood-Brain Barrier Permeability and Safety Profile
Can a nasal spray reverse brain aging? A new study shows that intranasal extracellular vesicles can clear brain fog, recharge mitochondria, and improve memory.
International Business Times Singapore: Nasal Spray Reverses Brain Inflammation and Memory Loss in Mice Study; Human Trials Next
A study found a nasal spray reduced brain inflammation and improved memory in mice, suggesting potential for aging-related decline.